"With the continued aging of the population and the growing epidemic of Alzheimer's, early detection of the disease is crucial for risk assessment, testing new therapies, and eventual early intervention with better drugs, once they are developed," said Ronald Petersen, chair or the Alzheimer's Association Medical & Scientific Advisory Council.
The scientists at Trinity College identified 345 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (81 with Alzheimer's, 163 with amnestic MCI, 101 elderly healthy controls) on whom there was available data including (a) cerebrospinal fluid (CSF) concentration and ratios of Alzheimer's related proteins: total tau, phosphorylated tau (p-tau181), and beta-amyloid (Aβ1-42), (b) MRI volume measures of certain sections of the brain, including the left and right hippocampus, entorhinal cortex, and medial temporal lobe, and (c) scores on certain standard memory, learning and brain function tests, including the Rey Auditory Verbal Learning test (RAVL) and the Alzheimer's Disease Assessment Scale (ADAS).
From this data they used statistical methods to identify the best set of predictors that correctly identified (a) healthy people versus those with Alzheimer's, and (b) people with mild cognitive impairment (MCI) who progressed to Alzheimer's.
"A substantial proportion of people with MCI may revert back to normal or may not develop Alzheimer's for years. Thus, the challenging task is to discern which of people with MCI have the Alzheimer's brain changes”, said Michael Ewers, senior research fellow at Trinity College Institute of Neuroscience.
The researchers found that results of three subunits of the memory tests could be combined to reach a classification accuracy of 89.9% for distinguishing people who progressed from MCI to Alzheimer's versus healthy people. They found that by adding in results from MRI volume measurements of the left hippocampus – a brain region closely linked to memory and Alzheimer's – they could increase classification accuracy to 94%. When, as a means to validate the findings, the same set of tests and measures was applied to distinguish the healthy people from those with Alzheimer's, classification accuracy was 95.7%.
COMPAMED.de; Source: Alzheimer’s Association