Microscopic sensor for more precise radiology treatments

11/23/2016

A team of Norwegian, French and Australian researchers is the first in the world to succeed in quantifying the effects of radiation on individual cancer cells. This means that radiation therapies can now be tailored to individual tumors and thus be more effective.

Image: Two researchers in a cleanroom; Copyright: SINTEF

SINTEF researchers Marco Povoli and Angela Kok have contributed towards the development of a microscopic sensor that measures what no other sensor can – the radiation doses absorbed by individual cancer cells; ©SINTEF

The recently developed sensor is the first of its kind and can measure radiation doses at the level of the individual cell in mixed radiation fields, that means measuring all type of radiation at the same time. It enables doctors to obtain a complete picture of how much damage each cell has incurred following treatment.

"This technology means that doctors can monitor and control radiation doses to make sure that only cancer cells are destroyed, with only minimal damage to surrounding healthy tissue", explains physicist and SINTEF researcher Angela Kok. Kok has been leading the work to develop the sensor as part of her day-to-day research looking into microsystems and nanotechnology.

Until now, quantification of the radiation dose absorbed by an individual cancer cell has been regarded as a very difficult task. Firstly, each cell is very small, and there may be as many as about a million cells in a single cubic millimeter of tissue. For this reason, and to ensure that the resulting data are correct, a sensor designed to measure radiation has to be as small as the cell itself. In other words, there has to be space for a million sensors in a single cubic millimeter of cancer tissue.

The second problem is that the cells themselves "perceive" the radiation dose in an entirely different way to the sensors. This is why, until now, no sensor has been able to quantify the actual degree of damage caused to cells by a radiation dose.

But the international research team has now succeeded in solving both of these problems.

The sensor size issue has been addressed simply by developing a sensor that is as small as a cancer cell. This has been achieved using a technology called semiconductor processing.

The second problem, addressing the different ways in which cells and sensors perceive radiation doses, represented a major challenge. But researchers solved this problem by encapsulating the sensors in a plastic material that mimics human tissue. In this way, the radiation dose measured by the sensors is almost identical to that absorbed by real cancer cells.

The measuring instrument contains microsensors placed alongside each other in a way that creates a "sheet" of sensors mounted on the silicon base. Dispersal across a given area enables the sensors to provide an image of the location within the cell that absorbs the highest levels of radiation. "In simple terms, we can say that the sensors are used to map variations in radiation intensity absorbed across the exposed cell", explains Kok.

The most important component of the new sensor is the element silicon, which is a semiconductor with radiation detection properties. "When radiation counteracts with silicon the energy is converted into a measurable electrical signal", explains Kok. "The magnitude of the signal indicates the intensity of the radiation", she says.

The very first sensor prototype saw the light of day at SINTEF's microsystems and nanotechnology lab following a major multinational project involving researchers in the field of medical radiation physics. It was tested recently at the European Synchrotron Radiation Facility (ESRF*) in Grenoble with outstanding results. It has also been tested by Australian researchers at the Australian Nuclear Science and Technology Organisation.

"This project is a little unusual because our research has resulted in new and fundamental knowledge about what happens in a volume of silicon that has the same dimensions as a typical cell", says Senior Research Scientist Kari Schjølberg-Henriksen, who has been working with quality assurance on this project. "We have taken this knowledge further and have seen it applied in practice after only four years", she says.

Research scientist Marco Povoli has been working on this project both as a SINTEF employee and as part of his post-doctoral studies at the University of Oslo. He believes that this innovation may be good news for the future development of cancer treatments using proton therapy.

The sensor has now been tested with excellent results. According to the research team, it is capable of measuring the true values of radiation doses absorbed by tissue, and with a better spatial resolution than existing equipment. The team is now hoping to be able to contribute towards the future development of radiation therapies for cancer. This can be achieved by providing a more precise quantification of the radiation doses absorbed by cancer tissue, while at the same time reducing the damage incurred by healthy tissue.

COMPAMED-tradefair.com; Source: SINTEF

More about SINTEF at: www.sintef.no/en