Premium Exhibitor Manufacturers Service

Institute of Isotopes Co., Ltd.

Konkoly Thege Miklos ut. 29-33 , 1121 Budapest
Hungary

Telephone +36 1 3922577
Fax +36 1 3959247
commerce@izotop.hu

Trade fair hall

  • Hall 1 / A42
 Interactive Plan

Hall map

MEDICA 2016 hall map (Hall 1): stand A42

Fairground map

MEDICA 2016 fairground map: Hall 1

Our range of products

Product categories

  • 01  Electromedical equipment / Medical Technology
  • 01.02  Imaging proceedings
  • 01.02.03  Nuclear medicine equipment

Nuclear medicine equipment

  • 01  Electromedical equipment / Medical Technology
  • 01.02  Imaging proceedings
  • 01.02.03  Nuclear medicine equipment
  • 01.02.03.04  Dosimeters

Dosimeters

  • 01  Electromedical equipment / Medical Technology
  • 01.02  Imaging proceedings
  • 01.02.03  Nuclear medicine equipment
  • 01.02.03.11  Nuclear diagnostic

Nuclear diagnostic

  • 01  Electromedical equipment / Medical Technology
  • 01.02  Imaging proceedings
  • 01.02.03  Nuclear medicine equipment
  • 01.02.03.15  Apparatus and accessories for therapeutic uses of nuclear medicine

Apparatus and accessories for therapeutic uses of nuclear medicine

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.03  Auto-immune diseases
  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.03  Auto-immune diseases
  • 03.02.03.01  Diagnostics / kits for the diabetes analyses

Diagnostics / kits for the diabetes analyses

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.04  Fertility / Pregnancy hormones / Proteins

Fertility / Pregnancy hormones / Proteins

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.06  Thyroid function hormones

Thyroid function hormones

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.06  Thyroid function hormones
  • 03.02.06.01  Diagnostic agents / kits for thyroid gland, etc. determination (Thyroid function hormones)

Diagnostic agents / kits for thyroid gland, etc. determination (Thyroid function hormones)

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.06  Thyroid function hormones
  • 03.02.06.04  Reagents for thyroid gland diagnostics

Reagents for thyroid gland diagnostics

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.07  Immuno assay systems

Immuno assay systems

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.07  Immuno assay systems
  • 03.02.07.06  Enzyme immunoassay (EIA, ELISA, EMIT)

Enzyme immunoassay (EIA, ELISA, EMIT)

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.07  Immuno assay systems
  • 03.02.07.14  Immunoradiometric assay (IRMA)

Immunoradiometric assay (IRMA)

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.07  Immuno assay systems
  • 03.02.07.21  Radioimmunoassay (RIA)

Radioimmunoassay (RIA)

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.09  Individual and specified hormones

Individual and specified hormones

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.09  Individual and specified hormones
  • 03.02.09.01  Diagnostic agents / kits for determination of growth hormones

Diagnostic agents / kits for determination of growth hormones

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.17  Tumor markers

Tumor markers

  • 03  Diagnostics
  • 03.02  Immunochemistry (Immunology)
  • 03.02.17  Tumor markers
  • 03.02.17.04  Reagents for tumour marker determination

Reagents for tumour marker determination

  • 07  Medical Services and Publications
  • 07.08  Logistic services

Logistic services

Our products

Product category: Auto-immune diseases, Individual and specified hormones

Rat, mouse Corticosterone ELISA KIT

The rat, mouse Corticosterone ELISA system
provides direct quantitative in vitro determination of rat and mouse Corticosterone in plasma and serum. Rat and mouse Corticosterone can be measured in the range 1.5-800 ng/mL. Each kit contains materials sufficient for 96 determinations permitting the construction of one standard curve and the assay of 40 unknowns in duplicate.

Introduction
The adrenal cortex produces 3 types of steroid hormones: glucocorticoids, mineralocorticoids and androgens or oestrogens. The glucocorticoids, which include corticosterone and cortisol, have important effects on carbohydrate and proteinmetabolism in mammals. Glucocorticoids are mainly produced in the inner layers of the adrenal cortex, the zona fasciculata and zona reticularis, as they contain the appropriate steroidogenic enzymes.
Synthesis of all adrenal steroids starts with the conversion of the common precursor cholesterol into pregnenolone and this is the main rate-limiting step. Corticosterone (MW346.5) is the main secreted glucocorticoid in the rat and rabbit while in man, monkey and sheep cortisol is the main secreted product. Cow,ferret, dog and cat secrete equal mixtures of both. Interestingly, cortisol and corticosterone are found in different biosynthetic pathways in the adrenal cortex. A characteristic 17.- hydroxylation of pregnenolone eventually leads to cortisol while corticosterone is one product in the pathway leading to the mineralocorticoid aldosterone. However, corticosterone possesses clear glucocorticoid activity and this is the main function in the rat.
Corticosterone is transported in the blood bound to a specific corticosteroid-binding globulin (CBG) (transcortin) which serves as a carrier and is in equilibrium with free steroid which is the active molecule. The mode of action of corticosterone is, as usual for steroids, that after interacting with cytosolic receptors the steroidreceptor complex binds to nuclear DNA to initiate transcription of  specific genes.
Corticosterone stimulates hepatic gluconeogenesis, increases hepatic glycogen content and blood glucose levels, promotes lipolysis and has a catabolic effect leading to a negative nitrogen balance. It is one of the mediators of the stress response to which these actions, which tend to oppose those of insulin, are an adaptation. Glucocorticoid secretion by the adrenal is stimulated by adrenocorticotrophin (ACTH) which acts to increase the rate of conversion of cholesterol to pregnenolone. Corticosterone acts in a negative feedback loop to inhibit the secretion of ACTH and corticotrophin releasing hormone (CRH) by the pituitary and hypothalamus respectively. This regulatory system is also influenced by other factors such as diurnal rhythm and stress. In the rat  corticosterone levels are at a peak in late afterno on and evening. Corticosterone concentrations can also be influenced by handling stress, anaesthesia, sex, and age in the rat.

More Less

About us

Company details

Institute of Isotopes Co., Ltd. is the major Hungarian center for the research, development and production of radioisotopes and other products for a broad range of application areas, especially healthcare, research and industry. Hundreds of products manufactured in our facilities are distributed worldwide.

The profile of our company is divided into four business lines:

1. Radiopharmaceuticals:

radiochemicals (I-125, I-131) radiopharmaceuticals (I-131, Sm-153, Y-90) powder injections: DMSA, DTPA, PYRON, FYTON, MDP, TECHIDA, EC, MULTIBONE

2. Immunoassay:

immunoassay kits for diagnostic (thyroid, tumor markers, protein hormones, Down syndrome etc.) and research purposes (RIA/IRMA)

3. Synthesis:

organic compounds labelled with C-14 or H-3 radioisotopes, custom synthesis, radiochemical repurification service for C-14, H-3 labelled compounds

4. Radiation Technique:

Ir-192 and Co-60 sealed industrial sources, laboratory and industrial gamma irradiators, hot cells, hot-cell lines, containers for transportation of radioactive material

More Less

Company data

Sales volume

10-49 Mio US $

Export content

> 75%

Number of employees

100-499

Foundation

1993

Area of business
  • Electromedical equipment / Medical Technology
  • Laboratory Equipment
  • Diagnostics