Reagent for determination of activated partial thromboplastin time (APTT) in human plasma
In presence of standardized amount of phospholipids (Cephalin), calcium chloride, and activator (kaolin), the factors of intrinsic coagulation system in citrated plasma are activated. The clotting time is measured.
The measure of APTT is a common coagulation test used for investigation of intrinsic coagulation pathway (factors VIII, IX, XI, XII, V, X, II and I). It is commonly used to monitor heparin therapy.
Abnormal APTT may require further investigations related to congenital or acquired deficiencies and should not be made a single test.