American Preclinical Services

8945, Evergreen Blvd., 55433 Minneapolis, MN

Telephone +1 763 7177990
Fax +1 763 7172042

This company is co-exhibitor of
Messe Düsseldorf North America

Trade fair hall

  • Hall 16 / E10-1
 Interactive Plan

Hall map

MEDICA 2016 hall map (Hall 16): stand E10-1

Fairground map

MEDICA 2016 fairground map: Hall 16

Our range of products

Product categories

  • 07  Medical Services and Publications
  • 07.04  Professional institutions

Our products

Product category: Professional institutions

Interventional & Surgical Research

American Preclinical Services specializes in medical device and combination product research. Within our one-of-a-kind research facility, highly skilled interventionalists, surgeons and clinicians use the latest, most powerful tools and techniques to perform the research you require. Their in depth experience across a wide variety of devices and procedures assures your project is performed in a precise, professional and timely manner.

Acute and Chronic, feasibility to GLP safety Medical Device Studies
On your behalf, APS can perform a full range of studies for medical devices. Our study designs have been used for comparative trials, 510(k) submissions, long-term safety studies for novel PMA devices, complex safety and pharmacokinetics trials for combination devices, and more.

Every step of the way, the APS team of scientists, study directors, technicians, and quality professionals are standing by to assist you.

We offer a world class facility for performing complex implant and treatment procedures that meet the demands of today’s medical devices. Our operating suites have the latest medical imaging equipment. The combination of advanced imaging systems and technical expertise will help bridge preclinical trials into human clinical trials.

The unique campus at APS gives you preclinical services for any medical device. We are able to source test systems, develop preclinical models, perform implant and treatment procedures, collect detailed study data, and synthesize a comprehensive study report. All these areas are fully supported by our ISO 17025 accredited and GLP compliant quality systems. You can depend on APS to provide you a well designed, well executed study culminating in reliable data and quality final reports.

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Product category: Professional institutions

Biocompatibility Testing

American Preclinical Services offers a full biocompatibility testing program. Here at APS, we take the time to understand the specifics of your medical devices and we take a clinically relevant approach to designing and implementing your panel of biocompatibility assays. At APS you benefit from:

A Team of professionals that understand the clinically indicated use of medical devices and assist in defining the appropriate biocompatibility testing required for your device and developing any necessary custom techniques to allow for reliable testing of even the more complex medical devices.  
A variety of custom extractions to meet your device needs.
A focus on minimizing the number of devices used through extraction and test assay planning.
Biocompatibility testing according to ISO, USP, and JMHLW guidelines.
USDA-registered facilities that are accredited by ISO 17025 and the American Association for the Accreditation of Laboratory Animal Care (AAALAC).
Standard & Custom Protocols

APS offers both standard (ISO10993, USP <87>, USP <88> & JMHLW) and custom biocompatibility testing protocols for material and component evaluations, in-vivo and in-vitro testing.

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Product category: Professional institutions

Analytical Services

APS has added a 2000 ft² analytical laboratory equipped with state-of-the art instrumentations and exceptional personnel expertise providing GLP compliant analytical supports. The laboratory is equipped to provide a full range of analytical services to facilitate integration and overlapping of various study components such as pharmacokinetic, toxicology, biocompatibility, quality control, stability studies, purity and impurity characterization and profiling, leachables and extractable from container closure, implantable medical devices, drug carriers, drug delivery systems and packaging materials.
ThermoFisher TSQ Quantiva LC/MS
A Dionex Ultimate 3000 UPLC connected to a Triple-Stage Quadrupole Mass Spectrometer (MSMS) and Diode Array Detector (DAD). It operates in electrospray positive (ESI+) and negative (ESI-). Excellent sensitivity, speed and dynamic range for method development, validation and routine sample analysis with the ability to separate and quantify the most complex and challenging samples. 
ThermoFisher Trace 1300 GC/MS
The GC is connected to an ISQTM Mass Spectrometer and Flame Ionization Detector (FID).  The mass spectrometer has a mass range from 1.2-1100 u with industry leading low sensitivity for detection, quantification and identification of volatile and semi-volatile components based on their mass spectra and an extensive NIST Mass Spectral Library. The system is also equipped with static headspace analyzer and TriPlus RSH™ Autosampler for automated liquid and headspace injections.

Agilent ICP-MS
ICP-MS is the premier technique for trace metals analysis in biological fluids, tissues, medical devices extracts, pharmaceutical products, etc. The system is based on Octopole Reaction System (ORS) technology operating in Helium collision mode to remove interferences, provide highest level of performance, extreme sensitivity and a wide order of analytical dynamic range even in complex matrices. This unit allows for a powerful analysis while maintaining flexibility, automation and ease of use. 

Nicolet IS10 Mid Infrared FTIR Spectrometer with OMNIC Specta Material Characterization
FTIR is used to obtain an infrared spectrum of absorption or transmittance of a solid, liquid or gas for product identification or quantification. The FTIR spectrometer simultaneously collects high spectral resolution data over a wide spectral range. This confers a significant advantage over a dispersive spectrometer which measures intensity over a narrow range of wavelengths at a time.

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Product category: Professional institutions

Toxicology and Pharmacology

American Preclinical Services offers a variety of general toxicology, pharmacokinetics (PK), toxicokinetics (TK), absorption/distribution/metabolism/excretion (ADME), and safety pharmacology studies in both rodents and non-rodent animal models. Our facility offers many key features such as independently ventilated rodent cages, digital monitoring of animal rooms, microchip identification, and a high capacity for study starts to help meet your timelines.

APS is licensed by Minnesota Department of Health (MDH) for the use of a wide range of radioisotopes such as Calcium-45, Carbon-14, Hydrogen-3, Iodine-125, Iodine-131, and Phosphorus-32 commonly utilized in synthesis and in-vivo tracking of drugs and biologicals. We have dedicated in-vitro laboratory space, animal procedure rooms and housing for isotope use for a wide range of PK and ADME studies.

Routes of Dosing/Administration

Types of active materials Dosed

Low Molecular Weight Drugs
Complex Extracellular matrix
Cellular Therapy

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Product category: Professional institutions

Pain Research

APS offers a comprehensive portfolio of rodent pain models designed for the assessment of novel analgesic therapies. We have compiled a highly skilled team of experts in the field of behavioral pharmacology, with experience in the pharmaceutical, medical device, and CRO industries.

As we strive to be your partner in your discovery research efforts, we have built our offerings to encompass models and assays that cover a range of discovery needs. Whether you need to screen a large number of compounds quickly or need to fully characterize a single compound, APS has the capabilities and experience to help you meet your goals.

As experienced pain researchers, we recognize that pain can manifest itself in multiple and diverse ways: hypersensitivity, use-related pain behaviors, and pain-suppressed behaviors to name a few. As such, we have established multiple ways to assess pain-related behaviors and we are constantly striving to add to and refine our offerings.  

Our services include the following endpoints:
Mechanical Allodynia
Mechanical Hyperalgesia
Thermal Hyperalgesia
Weight Bearing
Grip Strenth
Joint Compresion
Spontaneous Flinching
Visceromotor Response (EMG)
Acute Nociception
Inetsinal Transit

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About us

Company details

Discover American Preclinical Services (APS)
APS is a State of the Art, AAALAC and ISO17025 accredited, USDA registered and GLP compliant Contract Research Organization (CRO) located in Minneapolis, MN specializing in medical device and pharmaceutical testing.

We are a preclinical center of excellence whose services catalogue includes ISO10993, USP <87>, USP <88>, JMHLW, custom biocompatibility testing, analytical testing, interventional, surgical, toxicology, pharmacology, pain, physician training and bioskills, animal model development and complete pathology services.

Whether your company is a startup or an established industry leader, our experienced scientific staff has the expertise to meet your research needs and timelines.  Pilot and screening evaluations, feasibility and efficacy testing or ultimately GLP safety studies of the finished product, you will have industry experts to rely on every step of the way. 

We strive to deliver comprehensive, yet rapid service with the understanding that in product development, the only constant is change. We’ve tailored our processes, capacity, and customer service to keep up with today’s fast paced business cycles. APS will go from a quote to a ready to implement study design with your time lines in full focus.

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