Ligands on a microchip
Glycans and polysaccharides are the microchip ligands for the diagnostics of oncological, autoimmune and infectious diseases because:
• Carbohydrate antigens in cells are most plastic towards pathological changes
• A considerable part of antibodies in human blood is directed to carbohydrates
• Carbohydrate antigens are chemically stable; their conformation does not become changed after chemical immobilization
• Principal antigens of bacteria are polysaccharides; they are species specific features
• Core structures of O-chains and N-chains of glycoproteines;
• Oligosaccharides from lipids;
• Antigens of blood groups АВ0, Ii, P;
• Antigens of blood group Lewis, and their sulfated and sialylated analogs;
• Synthetic carbohydrates: unnatural and those not common for mammals.
Information on a part of glycans presented on glycochip is open for users. It includes antigens of blood group systems ABH, Lewis, FS, Ii. This information may be useful during transfusions and transplantations, assay of mother/fetus incompatibility, etc.
Information about some glycans in composition of diagnostic signatures of the microchip is confidential for researchers and can be provided after the contact with Semiotik.
• Polysaccharides of pathogenic bacteria
• Polysaccharides of opportunistic pathogenic bacteria
These microorganisms include:
Shigella flexneri, Shigella dysenteriae, Shigella boydii, Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Proteus vulgaris, Proteus pinneri, Cronobacter sacazaki, etc.