Manufacturers

ZytoVision GmbH

Fischkai 1 , 27572 Bremerhaven
Germany

Telephone +49 471 4832300
Fax +49 471 4832509
info@zytovision.com

This company is co-exhibitor of
DiagnostikNet-BB Netzwerk Diagnostik Berlin-Brandenburg e.V.

Trade fair hall

  • Hall 3 / G60
 Interactive Plan

Hall map

MEDICA 2016 hall map (Hall 3): stand G60

Fairground map

MEDICA 2016 fairground map: Hall 3

Our range of products

Product categories

  • 03  Diagnostics
  • 03.01  Clinical chemistry
  • 03.01.07  Gene tests / molecular biological diagnostic

Our products

Product category: Gene tests / molecular biological diagnostic

ZytoLight®

ZytoLight® system uses directly labeled FISH probes, which eliminate the need to detect the probes with fluorophore-coupled antibodies. The unique ZytoLight® Direct Label System II and the ZytoLight®Repeat Subtraction Technique lead to:

Improved signal intensity
Advanced specificity and sensitivity
Less background

ZytoLight® products are designed for the identification of genetic aberrations e.g. translocations, deletions, amplifications, and chromosomal aneuploidies by Fluorescence in situ Hybridization (FISH) in formalin-fixed, paraffin-embedded tissue sections, cell samples, blood or bone marrow smears, and metaphase chromosome spreads. 

Method Description & ZytoLight® Fluorochromes
The ZytoLight® system uses direct labeled FISH probes. The probes are detected by fluorescence microscopy using appropriate filter sets. Due to an exciter filter, full-spectrum light, emitted by the microscope lamp, is reduced to light of a defined wavelength that specifically excites the fluorophore of the probe. This light is reflected onto the specimen by a dichroic mirror. The fluorophore emits light of longer wavelengths that passes the mirror. Finally, a barrier filter reduces the emitted light to a defined wavelength that can be detected.

Two factors that mainly influence FISH analyses:

Fluorochromes of the FISH probes
Appropriate filter sets

Please refer to your local distributor for precise information regarding the suitable filter sets.

ZytoLight® Kits – Convenient Solutions
For making FISH analysis reliable and user-friendly, all ZytoLight® FISH probes can be combined with the ZytoLight® FISH-Tissue Implementation Kit (Z-2028-5/-20) for FISH analyses on tissue specimens or with the ZytoLight® FISH-Cytology Implementation Kit (Z-2099-20) for FISH analyses on cytology specimens. Both Implementation Kits include all necessary pretreatment solutions, wash buffers and DAPI/Antifade solution and a detailed protocol to perform successful FISH experiments. Additionally, for some major targets, complete kits including probes and all necessary reagents are available.

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Product category: Gene tests / molecular biological diagnostic

FlexISH®

FlexISH® products are designed for identification of chromosomal aberrations on various specimens by Fluorescence in situ Hybridization (FISH). Using the FlexISH® products gives you the flexibility to choose  between a 1-day  (2 h hybridization) or a 2-day (overnight hybridization) protocol by adapting the hybridization time just according to your individual needs! 

FlexISH® brings Flexibility to Your FISH
FlexISH® maximizes your flexibility in terms of time and laboratory management. Hybridization time can be varied between 2 hours and overnight.
With a hybridization temperature of 37°C the FlexISH® protocol is fully compatible with routine workflows in pathology laboratories.
In a recent comparison study, overnight and short hybridization periods showed excellent correlation between the FISH results obtained with FlexISH®, ZytoLight®, and PathVysion ERBB2 probes1.
Short hybridization time does not negatively affect the performance, specimen quality or diagnostic result1.

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Product category: Gene tests / molecular biological diagnostic

ZytoDot® and ZytoDot® 2CTM

ZytoDot® and ZytoDot® 2CTM products are designed for the detection of aneuploidies, gene amplifications or gene deletions and translocations by Chromogenic in situ Hybridization (CISH) in formalin-fixed, paraffin-embedded tissue sections, cell samples, blood or bone marrow smears, and metaphase chromosome spreads. The advantages of CISH are:

Simultaneous observation of tissue morphology and CISH signals
Quick and easy interpretation of results comparable to IHC
Storage of slides at room temperature - CISH signals are permanent
No costly fluorescence microscope needed

Method Description - ZytoDot®
Single Color CISH for the Detection of Genomic Alterations
The ZytoDot® system uses Digoxigenin-labeled probes which are detected using a Mouse-anti-Digoxigenin antibody. This antibody is detected by a polymerized HRP-Goat-anti-Mouse antibody. The enzymatic reaction of DAB leads to the formation of strong permanent brown signals that can be visualized by light microscopy using a 40x objective.

Method Description - ZytoDot® 2CTM
2-Color CISH for the Detection of Genomic Alterations

The ZytoDot® 2CTM system uses DIG- and DNP-labeled probe cocktails targeting different genomic sections which are detected using a Mouse-anti-DIG/Rabbit-anti-DNP cocktail. These antibodies are detected by a unique cocktail of polymerized HRP-Goat-anti-Mouse/AP-Goat-anti-Rabbit antibodies. The enzymatic reaction of AP-Red and HRP-Green leads to the formation of strong permanent red respectively green signals that can be visualized by light microscopy.

ZytoDot® Kits and ZytoDot® 2CTM Kits – Convenient Solutions
All single color ZytoDot® CISH probes can be combined with the ZytoDot CISH Implementation Kit (C-3018-10/-40)
All dual color  ZytoDot® 2CTM CISH probes can be combined with the ZytoDot 2C CISH Implementation Kit (C-3044-10/-40)

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Product category: Gene tests / molecular biological diagnostic

ZytoFast®

The ZytoFast® products are designed for outstandingly fast detection and discrimination of human pathogen viruses, e.g. HPV, EBV, CMV, and the determination of lymphocyte clonality by detecting Ig-κ and Ig-λ light chain RNA by Chromogenic in situ Hybridization (CISH) in formalin-fixed, paraffin-embedded tissue sections and cell samples. The signal intensity of ZytoFast® probes is increased even more when using the  ZytoFast® PLUS Implementation Kits.

Method Description - ZytoFast®
The ZytoFast® system uses oligonucleotide probes tagged with Biotin which are detected using enzyme-conjugated streptavidin targeting the tag. The enzymatic reaction of chromogenic substrates, e.g. BCIP/NBT or AEC, leads to the formation of strong color precipitates that can be visualized by light microscopy.

Method Description - ZytoFast® PLUS
The ZytoFast® PLUS system uses Digoxigenin-labeled probes which are detected using primary antibodies. These antibodies are detected by polymerized enzyme-conjugated secondary antibodies. The enzymatic reaction of chromogenic substrates, e.g. NBT/BCIP, AEC or DAB, leads to the formation of strong color precipitates that can be visualized by light microscopy.

ZytoFast® - Flexibility that meets your needs 
All Biotin-labeled probes can be combined with a ZytoFast® CISH Implementation Kit
All Digoxigenin-labeled probes can be combined with any of the ZytoFast® PLUS CISH Implementation Kits

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Product category: Gene tests / molecular biological diagnostic

VisionArray ® HPV Chip – Fast and Reliable Genotyping

The human papillomavirus (HPV) has been conclusively identified as the major risk factor for cervical cancer. It is the third most common cancer in women worldwide, with an estimated number of 530,000 new cases and 280,000 deaths each year. Currently more than 150 HPV types are well characterized which are classified as high-risk and low-risk types depending on the risk of progression from mild dysplasia to cancer.
The VisionArray HPV Chip is intended to be used with the VisionArray Analysis Package for the qualitative detection and genotyping of PCR amplificates of 41 clinically relevant HPV genotypes that have been produced with the help of the VisionArray HPV Primer Kit and the VisionArray Detection Kit.
 
VisionArray ® Analysis Package

The VisionArray Analysis Package stands for a simple visualization and a quick analysis of the VisionArray Chip data. The analysis of a chip and the report of the results can be achieved in just a few minutes.

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About us

Company details

ZytoVision GmbH develops and produces in situ hybridization (ISH)-based solutions for supporting diagnoses and treatment decisions of various diseases, particularly cancer.

The products are distributed by a worldwide network of distributors. Based on the certification ISO 13485, most of the products have been CE-marked for in vitro diagnostic (IVD) use.

ZytoVision is strongly focused on development of companion diagnostics which allow application of targeted and individual therapy in cancer. Additionally, in clinical trials, designed to approve new powerful drugs based on companion diagnostics, ZytoVision comprise development of validated ISH assays, molecular profiling of patients, and development of companion diagnostics.

Currently, more than 230 products are on offer in three different product lines: ZytoDot ®, ZytoLight ®, and ZytoFast ®. End customers of the ZytoVision GmbH are clinicians and pathologists who can provide improved clinical diagnoses based on ISH-techniques (FISH, and CISH respectively).

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Company data

Foundation

2004

Area of business

Diagnostics