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Image: 3-D Structure of Molecular Scaffold SgK223; Copyright: Onisha Patel and the Walter and Eliza Hall Institute

3-D 'scaffold' map to help the search for new cancer treatments


Researchers have produced the first three-dimensional (3D) map of a molecular 'scaffold' called SgK223, known to play a critical role in the development and spread of aggressive breast, colon and pancreatic cancers.
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Image: colorful reconstruction of neurons in the adult fly mushroom body; Copyright: Takemura et al.

Electron microscopy uncovers unexpected connections in fruit fly brain


What was once thought to be a done-and-dusted map of the fruit fly brain has gotten a second look, and researchers have discovered that it's actually not done at all.
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Image: Nano-CT images of a velvet worm leg; Copyright: Müller, Pfeiffer / TUM /

Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs


Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers.
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Graphic: Docking one of the hit compound into human Carbonic Anhydrase II isoform; Copyright: Anton Shetnev

Chemists have created compounds that can treat glaucoma


Glaucoma is a serious disease associated with increased intraocular pressure which often leads to blindness. One of the ways to treat glaucoma is to reduce aqueous humour secretion in the ciliary body of the eye by suppressing (inhibiting) activity of special enzymes - carbonic anhydrases. Russian scientists have designed new compounds that can effectively reduce intraocular pressure.
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Image: 3D printed element of a bone; Copyright: RMIT University

Just-in-time 3-D implants set to transform tumor surgery


A major new Australian research project using 3D implants and robotic surgery is set to radically advance the way physicians surgically treat tumours and bone cancer.
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Image: A newborn under EEG monitoring; Copyright: S Vanhatalo

Artificial intelligence to evaluate brain maturity of preterm infants


University of Helsinki researchers have developed artificial intelligence software, which can evaluate the maturity of a preterm infant’s brain directly from an EEG.
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Image: Multicolored diploid Candida albicans fungi growing on an agar plate; Copyright: Wyss Institute at Harvard University

Driving drug resistance out of fungi


New gene drive targeting a fungal pathogen enables identification of virulence regulators and potential future combination therapies.
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Image: Lab-grown blood vessel; Copyright: University of Minnesota

New tissue-engineered blood vessel replacements one step closer to human trials


Researchers at the University of Minnesota have created a new lab-grown blood vessel replacement that is composed completely of biological materials, but surprisingly doesn't contain any living cells at implantation. The vessel, that could be used as an "off the shelf" graft for kidney dialysis patients, performed well in a recent study with nonhuman primates.
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Image: Depiction of a

Antibiotics from a 'molecular pencil sharpener'


Scientists at Rutgers University-New Brunswick and other institutions have discovered a "molecular pencil sharpener" that chews away its outer coating to release the powerful antibiotic microcin B17.
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Image: Test-tubes with blue liquids and hydrogel-balls; Copyright:

Method of accelerating the maturation of stem cells to form neurons discovered


Hydrogel can be used as a scaffold for engineering artificial brain tissue and promotes the development of neurons.
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