Self-assembling nano devices are now enlisted in the nanomedicine revolution, a story as told by researchers from Duke University and the University of Southern California. Their report covers two classes of self-assembled, nanoscale medical delivery devices currently used to transport drugs and also imaging materials across physiological barriers that they, acting by themselves, would be unable to cross.
"Nanoscale self-assembly devices are complex structures organized from simpler subcomponents - either naturally occurring or engineered - which assume complex structures difficult to attain by chemical synthesis," said Doctor Ashutosh Chilkoti, professor of biomedical engineering at Duke University. "Their disassociation can be triggered by external stimuli, which serve as mechanisms to release therapeutic payloads."
According to Chilkoti and his co-authors, Doctor Mingan Chen and Jonathan R. McDaniel of the Duke University Department of Biomedical Engineering, as well as Doctor J. Andrew MacKay of the University of Southern California Department of Pharmacology and Pharmaceutical Sciences, many biological events rely on structures that self-assemble or disassemble based on environmental changes or physiological needs. Such natural self-assemblies used in nanomedicine rely on multiple weak forces, such as those associated with viral capsids and proteins.
Engineered self-assemblies used in nanomedicine come in over five groups of structural shapes, including the micellar nanostructure. "We have recently developed a novel strategy that utilizes micelles self-assembled from recombinant polypeptides after attaching doxorubicin, a cancer drug, to deliver the drug," explained Chilkoti, who is also the director of the Duke University Center for Biologically Inspired Materials and Material Systems.
According to MacKay, the stability of micelles is important to their success or failure as drug delivery systems. "The stability of micelles has thermodynamic and kinetic components," he said. "All factors that influence micellar stability can be tuned at the genetic level. Thus, we believe that genetically encoded polypeptide micelles are likely to play an increasing role in the design of next generation nanoscale carriers of drug and imaging agents."
COMPAMED.de; Source: University of South Florida (USF Health)