For labelling of biomolecules, Kaivogen offers several different lanthanide chelates. Some of the lanthanides, especially europium, terbium and samarium, are known for their long life-time fluorescence, which enables measurements based on time-resolved fluorometry (TRF). Due to the long fluorescence life-time, the TRF-based assays typically improve assay sensitivity and reduce background signal caused, for example, by the sample matrix or the plastic surface of the plate. The lanthanide chelates are widely used in various types of bioaffinity assay from trisomy testing to screening of new drug candidates.
Kaivogen provides two different families of lanthanide chelates. The Kajo chelates are optimal for high sensitivity applications and demand a separate intensification step at the end of the assay. The Loisto chelates are intrinsically fluorescent. They can be used as donor labels in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays, or assays involving direct surface measurement. Kaivogen chelates provide you with cost efficient options for immuno-, TR-FRET- and nucleic acid hybridization assays. All chelates are delivered with a certificate of analysis.
Europium Fluorescence Intensifier (EFI)