TNC SILMA O.O.O of Moscow at MEDICA 2020 in Düsseldorf -- COMPAMED Trade Fair
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TNC SILMA O.O.O

Shipilovskaya St., 50-1-2, 115573 Moscow
Russian Federation
Telephone +7 495 2239100
Fax +7 495 2239100
info@enterosgel.ru

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This company is co-exhibitor of
Moscow Export Center ANPO

Contact

Alexander Khovanov

Head of Marketing
Marketing

English, German

Phone
+79152860365

Email
hovanov@enterosgel.ru

Olga Minchina

Marketing Manager
Marketing

English, French, Spanish, Italian

Phone
+79104837883

Email
minchina@enterosgel.ru

Our range of products

Product categories

  • 05  Commodities and consumer goods
  • 05.01  Universal medical commodities

Universal medical commodities

  • 05  Commodities and consumer goods
  • 05.17  Other commodities and consumer goods

Other commodities and consumer goods

Our products

Product category: Other commodities and consumer goods

Sachets

Enterosgel — OTC medicinal product, innovative oral intestinal adsorbent (enterosorbent) that helps eliminate toxins, allergens and pathogens from the body.
100 g of the product contain active ingredient - polymethylsiloxane polyhydrate 70 g (organic silicon), excipient - purified water 30 g.
Enterosgel is used for treating atopic dermatitis, psoriasis, diarrhoea of various origin, food poisoning and alcohol intoxication.

Enterosgel in sachets  is perfect for on-the-go use. Sachets easily fit in any purse and can be taken on board of the aircraft

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Product category: Other commodities and consumer goods

90 g tube

Enterosgel in a 90 g tube is an optimal solution for office use and first aid kits at home and in the car.

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Product category: Other commodities and consumer goods

225 g tube

Tube 225 g is designed for families of more than 2 members or for course treatment. It is a convenient solution for home use.

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Company news

Date

Topic

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Nov 15, 2020

Enterosgel in Guidelines for Treatment and Prevention of COVID-19

In 2020, Enterosgel (active ingredient – polymethylsiloxane polyhydrate) has been included into the following guidelines:
  • Interim Guidelines: Prevention, Diagnosis and Treatment of the Novel Coronavirus Infection (COVID-19) – for pathogenetic treatment in cases of severe intoxication, abdominal pain, nausea and/or vomiting.
  • Guidelines. Medical Care For Pregnant Patients, Women In Labour, Puerperas, and Newborns With the Novel Coronavirus Infection Covid-19.
  • Diagnosis, Treatment And Prevention Of The Novel Coronavirus Infection (Covid-19): Guidelines for the Medical Personnel of the Armed Forces of the Russian Federation.
  • Interim Guidelines: Prevention, Diagnosis and Treatment of the Novel Coronavirus Infection (COVID-19)  in the Kyrgyz Republic.

     

     

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Nov 15, 2020

Enterosgel - intestinal adsorbent No.1 on the Russian & CIS intestinal adsorbent market (DSM Group 2020)

Enterosgel — OTC medical product, innovative oral intestinal adsorbent (enterosorbent) that helps eliminate toxins, allergens and pathogens from the body.

100 g of the product contain active ingredient - polymethylsiloxane polyhydrate 70 g (organic silicon), excipient - purified water 30 g.

Enterosgel is used for treating atopic dermatitis, psoriasis, diarrhoea of various origin, food poisoning and alcohol intoxication.

Enterosgel can be used by:

•       Pregnant and breastfeeding women
•       Infants and children (0+)
•       Diabetes patients
•       Allergy patients
•       Patients with gastric ulcer and duodenal ulcer
•       Vegans, vegetarians, etc.

Enterosgel does not contain substances that can cause allergic or toxic reactions.

Enterosgel is not metabolized, and does not penetrate into blood stream.

Product is registered in: Europe, Middle East, Asia, Latin America, Australia & New Zealand.

Enterosgel has been on the market for over 30 years.

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Nov 15, 2020

What is enterosorption?

The term “enterosorption” was first defined as the net gain of substances into the alimentary canal and in the context of a method of sorption therapy using orally administered sorbent materials or “enterosorbents”, was first used in the Soviet Union.

Enterosorbents are a group of materials which include activated carbons or charcoals, inorganic minerals, polymeric and silicon-containing resins. More recently they have been termed oral or intestinal adsorbents.

The term enterosorption is used to describe the process in which an enterosorbent travels along the gastrointestinal tract during which time it can adsorb certain molecules, but itself is neither absorbed from the gut into the systemic circulation, nor metabolised and is thus excreted unchanged. Charcoal has been used medically for many centuries, but it is only since the 1940s that its gastrointestinal adsorbent capacity has been demonstrated. For acute poisoning activated charcoal use is the intervention of choice to eliminate the poison from the gastrointestinal tract (GIT) and prevent its absorption by the body. Enterosorbents derived from calcium montmorillonite clays, such as NovaSil have been shown to adsorb aflatoxin B1 in vitro and be clinically effective in decreasing biomarkers of aflatoxin in the blood. However, charcoal is limited to short-term use as they are potent non-selective adsorbents. Regular use of enterosorbents over a longer period to treat medical conditions associated with chronic intoxication where sequestration of gut of toxins produced by the body or from bacterial species could be beneficial to patients, require a different set of physicochemical characteristics than for acute poisoning treatment. These include a material that is safe to be used over the longer-term, which can still adsorb target molecules such as bacterial toxins but shows negligible interactions with medications and micronutrients.

Enterosgel is an enterosorbent with an excellent safety record for over 30 years in the CIS countries, where it has been used in newborns to the elderly. It is listed in the governmental guidelines to treat wide range of pathologies from acute intestinal infections to side effects of chemo- and radiotherapy. In Europe, Enterosgel is a class IIa medical device and recommended as a symptomatic treatment of acute diarrhoea and chronic diarrhoea associated with Irritable Bowel Syndrome (IBS). Recent clinical studies have confirmed that Enterosgel improves the outcome in children and adults with acute diarrhoea (gastroenteritis), chronic diarrhoea including IBS with diarrhoea (IBS-D) and therapy induced diarrhoea in cancer patients.

Enterosgel is an organosilicon compound, polymethylsiloxane polyhydrate (PMSPH) which is formed from methylsiloxane by polycondensation. It comprises microglobules which contain porous space filled with water; these connect into larger particles (<250 µm in size) forming a hydrogel. The gel is amorphous and insoluble in water. Owing to its gelatinous nature, Enterosgel has a unique porous structure with a specific surface area of 150–250 m2/g dry weight. It has pores in the microporous range (below 2 nm in diameter) but mostly wide mesopores and small macropores in the range from 2 nm up to 100 nm in diameter. Enterosgel is composed of PMSPH and water in the ratio of 70/30 by weight, which has been found experimentally to have the highest pore volume ca. 1.5–1.6 cm3/g.

Generally, enterosorbents are non-selective in their adsorption, however, Enterosgel is reported as having an unusual and unique adsorption profile, showing an increasing sorption capacity with the increase in the molecular weight of the solute. This characteristic could be advantageous in limiting the unwanted adsorption of small molecules such as pharmaceutical drugs. Previous studies by Bardakhivska, et al., have shown that Enterosgel has lower adsorption activity towards certain anti-tuberculosis and anti-HIV preparations compared to activated charcoal.

Although Enterosgel is used in many clinical applications, the main mechanism of therapeutic action is still not fully understood; it is thought to be molecular adsorption of biological toxins from the gut. In this article we investigated Enterosgel’s mechanism of action, by examining in vitro adsorption capacity for bacterial toxins and bile acids, and interaction with the selected pharmaceutical drugs Cetirizine and Amitriptyline hydrochloride, assessing Enterosgel’s potential as a supportive therapy in complex treatment of conditions associated with the build-up of toxins in the GIT.*

*Howell, C.A., Mikhalovsky, S.V., Markaryan, E.N. et al. Investigation of the adsorption capacity of the enterosorbent Enterosgel for a range of bacterial toxins, bile acids and pharmaceutical drugs. Sci Rep 9, 5629 (2019). https://doi.org/10.1038/s41598-019-42176-z

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About us

Company details

Enterosgel is an oral intestinal adsorbent. Intestinal adsorbent is a substance that adsorbs toxins in GIT and then is naturally expelled from the body with the stool.

Allergens, viruses and bacterial toxins can affect the gut flora and the digestive health.

Enterosgel is a gel-like adsorbent created to help eliminate bacterial toxins, allergens and viruses from the body.

A number of studies have shown that Enterosgel helps:

  • Relieve or eliminate toxic and allergic reactions.
  • Stop diarrhoea or shorten its duration.
  • Accelerate the withdrawal of alcohol and its metabolic products.
  • Preserve beneficial gut microflora.
  • Reduce the toxic load on the liver and kidneys.
20 years on the CIS pharmaceutical market! Over-The-Counter (OTC).

Enterosgel is well-tolerated by children and adults and has no reports of severe adverse reactions. It can be used in conjunction with other medicines. Enterosgel should be taken 1-2 hours before or after meal and intake of other medicines.

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Company data

Number of employees

100-499

Company information as a PDF file